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pegfr tyr1068 assay kits  (Meso Scale Diagnostics LLC)

 
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    Meso Scale Diagnostics LLC pegfr tyr1068 assay kits
    Pegfr Tyr1068 Assay Kits, supplied by Meso Scale Diagnostics LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pegfr+tyr1068+assay+kits/pegfr+tyr1068+assay+kits/us09951064-1618-18-16
    Average 90 stars, based on 1 article reviews
    pegfr tyr1068 assay kits - by Bioz Stars, 2026-10
    90/100 stars

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    Mutagenesis:

    Article Title: Azaindazole compounds as inhibitors of T790M containing EGFR mutants
    Article Snippet: .. Potency of compounds to inhibit phosphor-EGFR in H1975(L585R/T790M) mutant EGFR expressing cells is determined using the Meso Scale Discovery 384 well pEGFR Tyr1068 assay kits. (Meso Scale Discovery Catalog# N31CB-1). .. Cell Culture: NCI-H1975 (ATCC Catalog# CRL-5908) cells are maintained in medium containing RPMI 1640, 10% FBS, 4 mM L-Glutamine, 1% Penicillin-Streptomycin, and 4.5 g/L Glucose.

    Article Title: Aminopyrimidine compounds as inhibitors of T790M containing EGFR mutants
    Article Snippet: .. Potency of compounds to inhibit phosphor-EGFR in H1975(L585R/T790M) mutant EGFR expressing cells is determined using the Meso Scale Discovery 384 well pEGFR Tyr1068 assay kits. (Meso Scale Discovery Catalog# N31CB-1). .. Cell Culture: NCI-H1975 (ATCC Catalog# CRL-5908) cells are maintained in medium containing RPMI 1640, 10% FBS, 4 mM L-Glutamine, 1% Penicillin-Streptomycin, and 4.5 g/L Glucose.

    Expressing:

    Article Title: Azaindazole compounds as inhibitors of T790M containing EGFR mutants
    Article Snippet: .. Potency of compounds to inhibit phosphor-EGFR in H1975(L585R/T790M) mutant EGFR expressing cells is determined using the Meso Scale Discovery 384 well pEGFR Tyr1068 assay kits. (Meso Scale Discovery Catalog# N31CB-1). .. Cell Culture: NCI-H1975 (ATCC Catalog# CRL-5908) cells are maintained in medium containing RPMI 1640, 10% FBS, 4 mM L-Glutamine, 1% Penicillin-Streptomycin, and 4.5 g/L Glucose.

    Article Title: Aminopyrimidine compounds as inhibitors of T790M containing EGFR mutants
    Article Snippet: .. Potency of compounds to inhibit phosphor-EGFR in H1975(L585R/T790M) mutant EGFR expressing cells is determined using the Meso Scale Discovery 384 well pEGFR Tyr1068 assay kits. (Meso Scale Discovery Catalog# N31CB-1). .. Cell Culture: NCI-H1975 (ATCC Catalog# CRL-5908) cells are maintained in medium containing RPMI 1640, 10% FBS, 4 mM L-Glutamine, 1% Penicillin-Streptomycin, and 4.5 g/L Glucose.

    Article Title: Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.
    Article Snippet: Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case History Robert Andrew Heald, Bryan K Chan, 2.. Callie Bryan, Charles Eigenbrot, Christine Yu, Daniel Burdick, Emily J. Hanan, Emily Chan, Gabriele Schaefer, Hank La, Hans Purkey, Jamie Knight, Ivana Yen, Philip Jackson, Krista Bowman, Kyle Mortara, Michael Lainchbury, Lily Shao, Richard Elliott, Eileen Seward, Shiva Malek, Stephen Schmidt, Steve Sideris, Timothy P Heffron, Kuen Yeap, Yuan Chen, and Sam Mann



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    Cell Signaling Technology Inc pegfr
    BCAP31 interacts with EGFR and facilitates ligand-independent EGFR/AKT pathway activation. (A) Mass spectrometry (MS) analysis of BCAP31-associated proteins. The purified protein complex was resolved on SDS-PAGE, followed by silver staining; then, the bands were retrieved and analysed by MS. (B) Analyses of the identified BCAP31 interactors. The diagram depicts BCAP31 interactors as detected by MS. The network was built based on the interaction network of EGFR-associated signalling and trafficking processes in the KEGG database overlaid with MS data. (C and D) The interaction between exogenous and endogenous BCAP31 and EGFR. Co-IP assay and immunoblot analyses evaluating the BCAP31-EGFR interaction in COS-7 cells and TNBC cells. (E) Downregulation of BCAP31 significantly attenuates ligand-independent signalling. TNBC cells stably expressed shBCAP31, control shRNA, or shRES when treated with EGF or EGF combined with gefitinib. IB examinations of phosphorylated EGFR and downstream signalling are shown. (F) Re-expression of the K721A kinase-dead (EGFR KD ) EGFR rescues the ligand-independent phosphorylation of EGFR at Tyr 845 and downstream AKT signalling in EGFR-knockdown MDA-MB-231 cells expressing control shRNA but not shBCAP31. SiRNA-resistant EGFR-KD was expressed in control or shBCAP31-MDA-MB-231 cells by lentivirus-mediated infection. Endogenous EGFR was knocked down by siRNA, and whole-cell lysate was harvested for western blot analysis. (G) Tumours of MDA-MB-231 tumour xenografts were harvested, homogenized, and analysed for <t>pEGFR</t> <t>(Tyr1068,</t> <t>Tyr845),</t> pAKT (Ser473), total EGFR and total AKT by ELISA. Statistical significance was determined using Dunnett's test.
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    pegfr tyr1068 assay kits  (Meso Scale Diagnostics LLC)
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    Meso Scale Diagnostics LLC pegfr tyr1068 assay kits
    BCAP31 interacts with EGFR and facilitates ligand-independent EGFR/AKT pathway activation. (A) Mass spectrometry (MS) analysis of BCAP31-associated proteins. The purified protein complex was resolved on SDS-PAGE, followed by silver staining; then, the bands were retrieved and analysed by MS. (B) Analyses of the identified BCAP31 interactors. The diagram depicts BCAP31 interactors as detected by MS. The network was built based on the interaction network of EGFR-associated signalling and trafficking processes in the KEGG database overlaid with MS data. (C and D) The interaction between exogenous and endogenous BCAP31 and EGFR. Co-IP assay and immunoblot analyses evaluating the BCAP31-EGFR interaction in COS-7 cells and TNBC cells. (E) Downregulation of BCAP31 significantly attenuates ligand-independent signalling. TNBC cells stably expressed shBCAP31, control shRNA, or shRES when treated with EGF or EGF combined with gefitinib. IB examinations of phosphorylated EGFR and downstream signalling are shown. (F) Re-expression of the K721A kinase-dead (EGFR KD ) EGFR rescues the ligand-independent phosphorylation of EGFR at Tyr 845 and downstream AKT signalling in EGFR-knockdown MDA-MB-231 cells expressing control shRNA but not shBCAP31. SiRNA-resistant EGFR-KD was expressed in control or shBCAP31-MDA-MB-231 cells by lentivirus-mediated infection. Endogenous EGFR was knocked down by siRNA, and whole-cell lysate was harvested for western blot analysis. (G) Tumours of MDA-MB-231 tumour xenografts were harvested, homogenized, and analysed for <t>pEGFR</t> <t>(Tyr1068,</t> <t>Tyr845),</t> pAKT (Ser473), total EGFR and total AKT by ELISA. Statistical significance was determined using Dunnett's test.
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    https://www.bioz.com/product/pegfr+tyr1068+assay+kits/pegfr+tyr1068+assay+kits/us09951064-1618-18-16
    Average 90 stars, based on 1 article reviews
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    Image Search Results


    BCAP31 interacts with EGFR and facilitates ligand-independent EGFR/AKT pathway activation. (A) Mass spectrometry (MS) analysis of BCAP31-associated proteins. The purified protein complex was resolved on SDS-PAGE, followed by silver staining; then, the bands were retrieved and analysed by MS. (B) Analyses of the identified BCAP31 interactors. The diagram depicts BCAP31 interactors as detected by MS. The network was built based on the interaction network of EGFR-associated signalling and trafficking processes in the KEGG database overlaid with MS data. (C and D) The interaction between exogenous and endogenous BCAP31 and EGFR. Co-IP assay and immunoblot analyses evaluating the BCAP31-EGFR interaction in COS-7 cells and TNBC cells. (E) Downregulation of BCAP31 significantly attenuates ligand-independent signalling. TNBC cells stably expressed shBCAP31, control shRNA, or shRES when treated with EGF or EGF combined with gefitinib. IB examinations of phosphorylated EGFR and downstream signalling are shown. (F) Re-expression of the K721A kinase-dead (EGFR KD ) EGFR rescues the ligand-independent phosphorylation of EGFR at Tyr 845 and downstream AKT signalling in EGFR-knockdown MDA-MB-231 cells expressing control shRNA but not shBCAP31. SiRNA-resistant EGFR-KD was expressed in control or shBCAP31-MDA-MB-231 cells by lentivirus-mediated infection. Endogenous EGFR was knocked down by siRNA, and whole-cell lysate was harvested for western blot analysis. (G) Tumours of MDA-MB-231 tumour xenografts were harvested, homogenized, and analysed for pEGFR (Tyr1068, Tyr845), pAKT (Ser473), total EGFR and total AKT by ELISA. Statistical significance was determined using Dunnett's test.

    Journal: Theranostics

    Article Title: BCAP31 drives TNBC development by modulating ligand-independent EGFR trafficking and spontaneous EGFR phosphorylation

    doi: 10.7150/thno.35383

    Figure Lengend Snippet: BCAP31 interacts with EGFR and facilitates ligand-independent EGFR/AKT pathway activation. (A) Mass spectrometry (MS) analysis of BCAP31-associated proteins. The purified protein complex was resolved on SDS-PAGE, followed by silver staining; then, the bands were retrieved and analysed by MS. (B) Analyses of the identified BCAP31 interactors. The diagram depicts BCAP31 interactors as detected by MS. The network was built based on the interaction network of EGFR-associated signalling and trafficking processes in the KEGG database overlaid with MS data. (C and D) The interaction between exogenous and endogenous BCAP31 and EGFR. Co-IP assay and immunoblot analyses evaluating the BCAP31-EGFR interaction in COS-7 cells and TNBC cells. (E) Downregulation of BCAP31 significantly attenuates ligand-independent signalling. TNBC cells stably expressed shBCAP31, control shRNA, or shRES when treated with EGF or EGF combined with gefitinib. IB examinations of phosphorylated EGFR and downstream signalling are shown. (F) Re-expression of the K721A kinase-dead (EGFR KD ) EGFR rescues the ligand-independent phosphorylation of EGFR at Tyr 845 and downstream AKT signalling in EGFR-knockdown MDA-MB-231 cells expressing control shRNA but not shBCAP31. SiRNA-resistant EGFR-KD was expressed in control or shBCAP31-MDA-MB-231 cells by lentivirus-mediated infection. Endogenous EGFR was knocked down by siRNA, and whole-cell lysate was harvested for western blot analysis. (G) Tumours of MDA-MB-231 tumour xenografts were harvested, homogenized, and analysed for pEGFR (Tyr1068, Tyr845), pAKT (Ser473), total EGFR and total AKT by ELISA. Statistical significance was determined using Dunnett's test.

    Article Snippet: All the ELISA kits were provided by Cell Signaling Technology, and the catalogue numbers are #7189 (Tyr845 of pEGFR), #7134 (Ser473 of pAKT), #7240 (Tyr1068 of pEGFR), and #7177 (Thr202/Tyr204 of pERK).

    Techniques: Activation Assay, Mass Spectrometry, Purification, SDS Page, Silver Staining, Co-Immunoprecipitation Assay, Western Blot, Stable Transfection, Control, shRNA, Expressing, Phospho-proteomics, Knockdown, Infection, Enzyme-linked Immunosorbent Assay